Contact Information

• Office:Room 1507, Researching Building 18

• Email: wpzhu@ecust.edu.cn

• Office Phone: +86 21 6425 3822

• Office Fax: +86 21 6425 2603

Education

• 2004.06 Ph.D.Chemical Engineering, East China University of Science &Technology, Shanghai, P. R. China

• 1992.06 M.Sc.Fine Chemicals, East China University of Science &Technology, Shanghai, P. R. China

• 1989.06 Eng.Applied Chemistry, National University of Defense &Technology, Changsha, P. R. China

Professional Experience

• 2010-now Professor, School of Pharmacy, East China Universityof Science and Technology

• 2005-2009  AssociateProfessor, School of Pharmacy, East China University of Science and Technology

Research Interests

• Construction of stimuli-responsive drug delivery systems

• Design of activable fluorescent probes for the diagnosis of diseases

Publications

1. Mingyang Hei, Huijing Wu, Yun Fu, Yufang Xu, Weiping Zhu*. Phenylboronic acid functionalized silica nanoparticles with enlarged ordered mesopores for efficient insulin loading and controlled release. Journal of Drug Delivery Science and Technology, 2019, 51(3), 320-326

2. Yao Tang, Hongyuan Shi, Di Cheng, Jing Zhang, Yuncheng Lin, Yufang Xu, Xuhong Qian, WeipingZhu*. pH-Activatable tumor-targeting gold nanoprobe for near-infrared fluorescence/CT dual-modal imaging in vivo. Colloids and Surfaces B: Biointerfaces, 2019, 179(7), 56-65

3. Houna Duan, Yu Ding, Chusen Huang,* Weiping Zhu,* Rui Wang, Yufang Xu. A lysosomal targeting fluorescent probe and its zinc imaging in SH-SY5Y human neuroblastoma cells. Chinese Chemical Letters, 2019, 30(1), 55-57

4. Yuezheng Ti, Ling Yu, Yao Tang, Tongxia Jin, Ming Yang, Rui Wang*, Yufang Xu, Weiping Zhu*. A hypoxia-activated near infrared fluorescent probe for cyclooxygenase-2 and in vivo imaging for tumor and inflammation, Sensors and Actuators B: Chemical, 2018, 265, 582-590

5. Huijing Wu, Junhua Jia, Yufang Xu, Xuhong Qian, and Weiping Zhu*. A reusable bifunctional fluorescent sensor for the detection and removal of silver ions in aqueous solutions, Sensors and Actuators B: Chemical, 2018, 265, 59-66

6. Mingyang Hei, Jun Wang, Kelly Wang, Weiping Zhu* and Peter X Ma*. Dually responsive mesoporous silica nanoparticles regulated by upper critical solution temperature polymers for intracellular drug delivery, J. Mater. Chem. B, 2017, 5, 9497-9501

7. Feng Yu, Huijing Wu, Yao Tang, Yufang Xu, Xuhong Qian, and Weiping Zhu*. Temperature-sensitive copolymer-coated fluorescent mesoporous silica nanoparticles as a reactive oxygen species activated drug delivery system, International Journal of Pharmaceutics, 2018, 536, 11-20

8. Dandan Li, Yuqiong Xu, Nannan Zhou, Jianxu Liu, Rui Wang, Tao Cheng, Yun Tang, Weiping Zhu, Yufang Xu,* Xuhong Qian*. A novel ‘‘donor-two-acceptor’’ type fluorophore-based probe for fast detection and intracellular imaging of nitroreductase, Dyes and Pigments, 2017, 136, 627-632

9. Xiaotong Jia, Qiangqiang Chen, Yingfang Yang, Yao Tang, Rui Wang, Yufang Xu, Weiping Zhu, Xuhong Qian*. A FRET-based Mito-Specific Fluorescent Probe for Ratiometric Detection and Imaging of Endogenous Peroxynitrite: Dyad of Cy3 and Cy5, Journal of American Chemistry Society, 2016, 138 (34), 10778–10781

10. Jingwen Zhang, Chao Wang, Lei Zhang, Huijing Wu, Yi Xiao,* Yufang Xu, Xuhong Qian and Weiping Zhu*. Novel nonplanar and rigid fluorophores with intensive emission in water and the application in two-photon imaging of live cells, RSC Advances, 2016, 6, 71624-72627

11. Yujie Li, Mingyang Hei, Yufang Xu, Xuhong Qian, Weiping Zhu*. Ammonium salt modified mesoporous silica nanoparticles for dual intracellular-responsive gene delivery, International Journal of Pharmaceutics, 2016, 511, 689-702

12. Qi Cai, Gaosheng Liang, Yufang Xu, Xuhong Qian*, and Weiping Zhu*. A Reusable Heterogeneous Catalyst without Palladium Leaking for High-efficient Suzuki-Miyaura Reaction in Pure Water under Air, RSC Advances, 2016, 6, 60996-61000

13. Yao Tang, Yu Liu, Yiqiao Qin, Yufang Xu, Xuhong Qian, and Weiping Zhu*. A reusable thioether-rich crown-based fluorescent sensor for the detection and removal of mercuric ions, Journal of Colloid and Interface Science, 2016, 479, 7-14

14. Junhua Jia, Luling Wu, Yu Ding, Chusen Huang, Weiping Zhu*, Yufang Xu and Xuhong Qian. A DPA-based highly selective and sensitive fluorescent probe for mercuric ions and its imaging in living cells, Dalton Transactions, 2016, 45, 9402-9406

15. Mengfang Tang, Luling Wu, Dan Wu, Chusen Huang, Weiping Zhu*, Yufang Xu and Xuhong Qian. An “Off-On” Fluorescent Probe for the Detection of Cysteine /Homocysteine and Its Imaging in Living Cells, RSC Advances, 2016, 6(41), 34996-35000

16. A highly selective fluorescent probe for fast detection of hydrogen sulfide in aqueous solution and living cells. Chemical Communications, 2012,48, 10871-10873

17. Modulating the selectivity by switching sensing media: a bifunctional chemosensor selectivity for Cd²⁺ and Pb²⁺ in different aqueous solutions, RSC Advances, 2012,2, 6323-6328

18. A highly selective and sensitive fluorescence “turn-on” probe for Ag⁺ in aqueous solution and live cells, Dalton Transactions, 2012,41, 7212-7217

19. Lin Xu, Yufang Xu, Weiping Zhu, Zheng Xu, Mengjie Chen and Xuhong Qian*. Fluorescence sensing of iodide and bromide in aqueous solution: anion ligand exchanging and metal ion removing, New Journal of Chemistry, 2012, 36, 1435–1438

20. Copper-promoted probe for nitric oxide based on o-phenylenediamine: Large blue-shift in absorption and fluorescence enhancement, Analytical Methods, 2012,4, 919-922

21. Derivatives of benzothiadiazole-7- carboxylates: synthesis and biological activity,Monatshefte für Chemie / Chemical Monthly, 2008, 139, 1067-1071